More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19Article Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 치료기술, 치료제, [키워드] Activation amplified amplify analyzed blocked Blood Cell chemokine chronic liver disease Chronic Liver Diseases circulating comorbid disease Comorbidity contribute controls correlated COVID-19 COVID-19 patients Critical cytokine cytokine secretion DCLK1 DDCLK1 decrease disease severity dysregulation expression Factor Factors Gain growth factor hospitalized patient Host Hyperinflammatory response immune Immune cell immune response immunosuppressive in viral in vitro infected cells Inflammation Inflammatory cytokine inflammatory pathway inhibition inhibitor Innate immunity involved kinase Live virus liver livers loss of function lung Lung disease Macrophage mononuclear cell mononuclear cells Mortality neutrophil normalized Pathogenesis pathology Patient Peripheral blood potential therapeutic target Prevalence pro-inflammatory profile proinflammatory promoted promoter Protein S100A9 SARS-CoV-2 SARS-CoV-2-infected cell secretion severity of COVID-19 Signaling subject targeting Treatment Viremia virus production virus replication Virus replication. with COVID-19 β-catenin [DOI] 10.1128/jvi.00967-22 PMC 바로가기
New Perspectives on Antimicrobial Agents: Molnupiravir and Nirmatrelvir/Ritonavir for Treatment of COVID-19항균제에 대한 새로운 관점: 코로나19 치료를 위한 몰누피라비르 및 니르마트렐비르/리토나비르Article Published on 2022-08-162022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted relative risk antimicrobial Antiviral cause childbearing potential children Complication Contraception coronavirus disease Coronavirus-2 COVID-19 cytochrome P450 Cytochrome P450 enzymes death drug Drug administration Drug-to-drug interaction Each Emergency use authorization food hospitalizations in vitro inhibit limit management medication metabolism Mild mild to moderate moderate molnupiravir morbidity and mortality Mutation New Nirmatrelvir nirmatrelvir/ritonavir. nonspecific outcome pandemic Patient polymerase polyprotein pregnant protease proteolytic cleavage reduction Relative risk Replication Respiratory disease risk Ritonavir SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly target tested Toxicity Treatment treatment regimen U.S. Food and Drug Administration variant viral replication virus virus production [DOI] 10.1128/aac.02404-21 PMC 바로가기 [Article Type] Article
Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse ModelArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Analysis antiviral drug cells coronavirus coronavirus protein Coronavirus replication coronavirus RNA COVID-19 pandemic death demonstrated effective EGCG enzyme epigallocatechin examined exhibited gallate green green tea HCoV-OC43 human coronavirus OC43 in vitro in vivo infected cells Infection inhibit inhibitory effect Lungs mice Model mouse polyphenol recent reduced SARS-CoV-2 scanning electron microscopy tea Treatment virion virus production [DOI] 10.3390/v13122533 PMC 바로가기 [Article Type] Article
Interferon-Lambda Intranasal Protection and Differential Sex Pathology in a Murine Model of SARS-CoV-2 InfectionSARS-CoV-2 감염의 쥐 모델에서 인터페론-람다 비강 내 보호 및 차등 성 병리학Research Article Published on 2021-11-022022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 치료제, [키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered angiotensin Antiviral antiviral agent blocked bronchial epithelial cell can be used coronavirus COVID-19 Culture decrease disease dissemination dose early stage early stages Efficacy enzyme epithelial cells expressing human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human lung cell human lung cells IFN-λ infected with SARS-CoV-2 Infection Infectious virus inhibit SARS-CoV-2 inhibited interferon Interferon lambda intranasally Lung infection male mice Model morbidity and mortality Mortality mouse model murine model outcome Pathogens pathology Patient primary human bronchial epithelial cells protection protective effect Protective effects reduce respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe symptom Sex significantly tested transgenic mice treat Treatment Viral viral pathogen viral pathogens virus production [DOI] 10.1128/mBio.02756-21 PMC 바로가기 [Article Type] Research Article
Ginkgolic Acid Inhibits Coronavirus Strain 229E Infection of Human Epithelial Lung CellsCommunication Published on 2021-09-262022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 229E acid added affected Antiviral antiviral activity Antiviral compound caused coronavirus Coronaviruses COVID-19 pandemic CPE Cytopathic effect deaths demonstrated disrupting Ebola effective effective antiviral treatment Efficacy epithelial Epstein Barr virus exhibited expression fusion inhibitor ginkgolic acid globe HCoV-229E Herpe HIV HSV-1 Human Human coronavirus in vitro in vivo individual Infection influenza A inhibit inhibited inhibiting lung cell Post-infection progeny Proteins reduced reported SARS-CoV-2 significantly similarity strain Vaccine Viral mutations Viral protein Viral proteins virus production viruses [DOI] 10.3390/ph14100980 PMC 바로가기 [Article Type] Communication
Modeling Within-Host Dynamics of SARS-CoV-2 Infection: A Case Study in FerretsArticle Published on 2021-08-182022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] animal model antiviral agent basic reproduction number Cell Characteristics COVID-19 death rate doubling Dynamics estimate ferret ferrets Global Sensitivity Analysis hosts Human infected cell Infection infection rate Infectious virus information mathematical modeling not significantly different parameter performed potential for transmission proportion respiratory tract SARS-CoV-2 similarity Support Trial viral dynamics viral growth viral infection viral strain virus clearance virus production while within-host modeling [DOI] 10.3390/v13081635 PMC 바로가기 [Article Type] Article
Incomplete antiviral treatment may induce longer durations of viral shedding during SARS-CoV-2 infection불완전한 항바이러스 치료는 SARS-CoV-2 감염 동안 더 긴 기간의 바이러스 배출을 유발할 수 있습니다Research Article Published on 2021-08-032022-09-10 Journal: Life Science Alliance [Category] MERS, SARS, 치료제, [키워드] antiviral drug antiviral drugs Antiviral treatment balance blocked with characterized de novo determined by driven by Efficacy Incomplete induce infected cells infected individual infected individuals Infection initiated Kinetics mathematical mathematical model Mathematical models non-human primate non-human primates predict quantified removal SARS-COV-2 infection treated Treatment uninfected cell uninfected cells Viral viral shedding virus virus production virus replication [DOI] 10.26508/lsa.202101049 PMC 바로가기 [Article Type] Research Article
A Novel Small Molecule Inhibits Hepatitis C Virus Propagation in Cell CultureResearch Article Published on 2021-07-282022-10-30 Journal: Microbiology Spectrum [Category] Coronavirus, SARS, [키워드] analysis antiviral agent Antiviral agents antiviral drug Antiviral effect approval caused Cell Cell culture cells line cellular chronic disease chronic infection curative docking study drug Drug discovery Effect HCV HCVcc hepatitis C hepatitis C virus infected cells Infection Infectious virus inhibited JFH-1 mechanism of action molecular molecule morbidity and mortality not affect novel NS5B pandemic Propagation Protein protein expression real-time RT-PCR reduced reduction in Replication RNA RNA polymerase SARS-CoV-2 significantly suggested treated Treatment viral life cycle viral replication Viral RNA virus virus virus inhibition virus production virus spread virus-infected cell was tested [DOI] 10.1128/Spectrum.00439-21 PMC 바로가기 [Article Type] Research Article
Viral MicroRNAs Encoded by Nucleocapsid Gene of SARS-CoV-2 Are Detected during Infection, and Targeting Metabolic Pathways in Host CellsSARS-CoV-2의 뉴클레오캡시드 유전자에 의해 암호화된 바이러스성 MicroRNA는 감염 중에 감지되고 숙주 세포에서 대사 경로를 표적화합니다Communication Published on 2021-07-122022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] absence association Biomarker Biosynthesis Calu-3 cell lines cellular interactions cellular metabolism conserved COVID-19 COVID-19 patients Critical deep sequencing disease disease pathogenesis DNA and RNA dysregulation effective expression functional Gene Expression host target genes identify immune dysregulation in silico analysis induce infective initial screening mapped mechanism metabolic metabolism microRNA MicroRNAs miRNA miRNAs N gene Pathogenesis pathogenesis of COVID-19 pathophysiology pathway Prevalence RNA sequence RNA viruses SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 strains selected shown Support target targeting the SARS-CoV-2 genome Therapeutic strategies therapeutic strategy Treatment v-miRNA v-miRNAs Vero E6 Viral Viral load viral miRNAs virus virus production viruses [DOI] 10.3390/cells10071762 PMC 바로가기 [Article Type] Communication